Major stock indices on Wall Street closed lower on Wednesday. The S&P 500 and the tech-heavy Nasdaq fell to their lowest level in three weeks, pressured by recurring trade concerns. The broader Topex index declined 0.37% to 3356.89 points. The Nikkei index dropped 1.03% to 49001.5 points, marking its lowest close since November 25. The Nikkei index ended trading on Thursday at a three-week low, weighed down by profit-taking in large-cap technology stocks with significant weight in the index, as investors assess the growth prospects of artificial intelligence and data center companies.
